Home > Academics > Academic Units > Faculty of Sciences (FoS) > Chemistry > Kiran Ramakant Gore
Assistant Professor Grade-I
Chemistry
Research Interests
Our lab work at the interface of organic synthesis and chemical biology. We are interested in the synthesis of chemically modified oligonucleotides (ASOs, siRNAs, aptamer, etc.) and testing their biochemical properties. We synthesize chemically modified oligonucleotides to improve stability, cellular uptake, and potency in therapeutic applications. Few projects are in the pipeline, such as synthesis and applications of fluorescent nucleosides to study nucleic acid interactions, targeted delivery of siRNAs, etc. We are also involved in the development of turn-on fluorescent probes for the detection of biologically important molecules such as cyanide, biological thiols, heavy metals, etc. In the area of synthetic chemistry, we are developing new methodologies in the synthesis of chemically modified nucleosides, developing optical probes, etc.
Folate Receptor-Mediated siRNA Delivery: Recent Developments and Future Directions for RNAi Therapeutics by Gore K. R., Gangopadhyay S. , Nikam R. R. Nucleic acid Therapeutics 1 - (2021)
LiHMDS: Facile, Highly Efficient, and Metal-Free Transesterification under Solvent-Free Condition by Gore K. R., Mittapelli L. L. Catalysis Communications 149 106194-106199 (2021)
Journey of siRNA: Clinical Developments and Targeted Delivery by Nikam R. R., Gore K. R. Nucleic Acid Therapeutics 1 209-224 (2018)
Novel Silylated HBI Analog for Rapid, Selective, and Sensitive Detection of Cyanide in Water and Living Cells by Mirajkar A. L., Mittapelli L. L., Nawale G. N., Gore K. R. Sensors and actuators B: Chemical 265 257-263 (2018)
large Stokes shift fluorogen-activating RNA aptamer by Steinmetzger C., Palaniswamy N. , Gore K. R., Höbartner C. Chemistry-European Journal 25 1931-1935 (2019)
The N2-Furfural Deoxyguanosine (fdG) Adduct Does Not Alters The Structure of B-DNA by Ghodke P., Gore K. R., Harikrishna S. , Samanta B. , Kottur J. , Nair D. T., Pradeepkumar P. I. Journal of Organic Chemistry 81 502-511 (2016)
Influence of 2 -Fluoro versus 2 -O-Methyl Substituent on the Sugar Puckering of 4 -C-Aminomethyl-uridine by Gore K. R., Harikrishna S. , Pradeepkumar P. I. Journal of Organic Chemistry 78 9956-9962 (2013)
Incorporation of 4'-C-Aminomethyl-2'-O-Methylthymidine into DNA by Thermophilic DNA Polymerases by Nawale G. N., Gore K. R., Höbartner C. , Pradeepkumar P. I. Chemical Communications 48 9619-9621 (2012)
Synthesis, Gene Silencing, and Molecular Modelling Studies of 4 -C-Aminomethyl-2 -O-Methyl-Modified Small Interfering RNAs by Gore K. R., Nawale G. N., Harikrishna S. , Chittoor V. , Pandey S. , Höbartner C. , Patankar S. , Pradeepkumar P. I. Journal of Organic Chemistry 77 3233-3245 (2012)
Carrier-Free Folate-siRNA Conjugates Bearing Diverse 4-C-Alkylamino-2-Fluoro-Pyrimidines to Evaluate the Targeted Delivery and Synergistic Gene Silencing in Cancers Science and Engineering Research Board (SERB)
Development of thermally stable additives and high performance water-based drilling fluids up to 230 C OIL AND NATURAL GAS CORPORATION LIMITED
Subhankar Santra
Area of Research: Heterocyclic chemistry
Sumit Gangopadhyay
Area of Research: Bio organic Chemistry
Gourav Das
Area of Research: Bioorganic Chemistry
Avijit Sahoo
Area of Research: Nucleic acid chemistry
Nishant Kumar Choudhary
Area of Research: Nucleic acid chemistry
Santanu Sar
Area of Research: Nucleic acid chemistry
Rahul Kumar
Area of Research: Bio organic Chemistry
Pilare Shivani Nandakishor
Area of Research: Nucleic acid Chemistry
